Products
Tetrakis (hydroxymethyl) phosphonium Sulfate (THPS) 55566-30-8 Biocide
We are a leading supplier of Tetrakis (hydroxymethyl) phosphonium sulfate (THPS) biocide, a safe liquid biocide that is used to control the growth of bacteria, algae and fungi in oilfield and industrial water treatment applications.
Our EPA registered THPS biocide formulations are commercialized under the brand name Avancid®.

What is Tetrakis(hydroxymethyl)-phosphonium Sulfate (THPS) biocide?
THPS is a safe aqueous solution with antimicrobial properties that is significantly less toxic, effective at lower concentrations, and more biodegradable than other traditional biocides.
Our THPS is available in different levels of active phosphorous contents to suit different applications. We sell our EPA registered concentrations under the AVANCID® brand name and offer non-registered THPS concentrations as well.
We have prime Environmental Protection Agency (EPA) registrations for the blending and formulation of tetrakis (hydroxymethyl) phosphonium sulfate (THPS) and glutaraldehyde.
CAS #: 55566-30-8
EINECS #: 259-709-0
Synonyms: Bis[tetrakis(hydroxymethyl)phosphonium] sulfate solution; Octakis (Hydroxymethyl) Diphosphonium Sulfate; THPS
Molecular Formula: C8H24O12P2S

Tetrakis(hydroxymethyl)phosphonium Sulfate (THPS) Biocide Applications
Oilfield Operations
Our various EPA registered, Avancid®, and non-registered concentrations of THPS, are effective broad spectrum microbicide chemistries used in oil & gas production applications. Avancid® THPS inhibits microbial growth in oilfield water flood operations, in oil & gas reservoirs, drilling muds, completions fluids, workover fluids and hydraulic fracturing operations. It is also compatible with other biocides and oxidizers.
Our non-registered formulations find also uses as iron control chemistries in acidic and alkaline environments dissolving iron sulfide scales and deposits and providing effective corrosion protection.
Industrial and Commercial Water Treatment
Our Avancid® Tetrakis Hydroxymethyl Phosphonium Sulfate (THPS) formulations can be also used for the control of bacteria, algae, and fungi in industrial/commercial recirculating cooling water systems, in heat transfer water systems, and in industrial process water systems.
Preservative
Our Avancid® Tetrakis Hydroxymethyl Phosphonium Sulfate (THPS) formulations present also preservative properties for controlling the growth of bacteria and fungi in water-based paints and coatings, adhesives, latex paints, starch pigment, extender slurries, paints, latex, and antifoam emulsion systems.
Textile Auxiliaries
THPS is of importance in the textile industry and is used to produce crease-resistant flame retardant finishes on cotton textiles and cellulosic fabrics. THPS is also an excellent organic tanning agent for the production of chrome and metal-free leathers.
Oilfield Operations
Our various EPA registered, Avancid®, and non-registered concentrations of THPS, are effective broad spectrum microbicide chemistries used in oil & gas production applications. Avancid® THPS inhibits microbial growth in oilfield water flood operations, in oil & gas reservoirs, drilling muds, completions fluids, workover fluids and hydraulic fracturing operations. It is also compatible with other biocides and oxidizers.
Our non-registered formulations find also uses as iron control chemistries in acidic and alkaline environments dissolving iron sulfide scales and deposits and providing effective corrosion protection.
Industrial and Commercial Water Treatment
Our Avancid® Tetrakis Hydroxymethyl Phosphonium Sulfate (THPS) formulations can be also used for the control of bacteria, algae, and fungi in industrial/commercial recirculating cooling water systems, in heat transfer water systems, and in industrial process water systems.
Preservative
Our Avancid® Tetrakis Hydroxymethyl Phosphonium Sulfate (THPS) formulations present also preservative properties for controlling the growth of bacteria and fungi in water-based paints and coatings, adhesives, latex paints, starch pigment, extender slurries, paints, latex, and antifoam emulsion systems.
Textile Auxiliaries
THPS is of importance in the textile industry and is used to produce crease-resistant flame retardant finishes on cotton textiles and cellulosic fabrics. THPS is also an excellent organic tanning agent for the production of chrome and metal-free leathers.
Tetrakis(hydroxymethyl)phosphonium Sulfate Biocide Concentrations
AVANCID® Series EPA Registered Biocides |
Avancid® 20
|
Avancid® 35 | Avancid® 50 | Avancid® 75 | Avancid® 75M |
EPA registration No.: | 74712-4 | 74712-11 | 74712-12 | 74712-3 | 74712-2 |
Active content, wt.% | 19.4 – 20.6 | 34.0 – 36.1 | 48.5 – 51.5 | 75.0 – 77.0 | 74.2 – 78.8 |
P content, wt.% | 5.3 – 5.7 | 7.6 – 8.0 | 11.4 – 11.8 | 11.4 – 11.8 | |
pH | 3.0 – 5.0 | 3.0 – 5.0 | 3.0 – 5.0 | 3.0 – 5.0 | 3.0 – 5.0 |
Specific Gravity (25°C) | 1.08 – 1.10 | 1.16 – 1.19 | 1.25 -1.28 | 1.37 – 1.40 | 1.37 – 1.40 |
Packaging and Handling
SMC Global offers THPS in customized packages and bulk quantities.
Tetrakis(hydroxymethyl)phosphonium Sulfate (THPS) Biocide Safety
For regulatory details such as the classification and labeling as dangerous substances or goods, please refer to our corresponding Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) Biocide Safety Data Sheet.